Kalamakis, G., Brune, D., Ravichandran, S., Bolz, J., Fan, W., Ziebell, F., & Martin-Villalba, A. Essential role of proteasomes in maintaining self-renewal in neural progenitor cells. The proliferation of amplifying neural progenitor cells is impaired in the aging brain and restored by the mtor pathway activation. Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. F., Cebrian-Silla, A., Sandoval, K., Qi, D., Kelley, K. Adult neurogenesis in humans: A review of basic concepts, history, current research, and clinical implications. In vivo imaging of adult human hippocampal neurogenesis: Progress, pitfalls and promise. Analysis of proliferating neuronal progenitors and immature neurons in the human hippocampus surgically removed from control and epileptic patients. Seki, T., Hori, T., Miyata, H., Maehara, M., & Namba, T. Mechanisms and functional implications of adult neurogenesis. It also shed light on the regulation of adult neurogenesis and paves the way for developing a therapeutic strategy for aging and neurodegenerative diseases. Taken together, our results reveal that compromised autophagy is involved in the decline of adult neurogenesis, which could be reversed by autophagy activation. More importantly, autophagic activation by rapamycin also ameliorated the olfactory sensitivity and cognitional capacities in middle-adult mice. Conversely, stimulating autophagy by rapamycin not only revitalized the viability of middle-adult NPCs, but also facilitated the neurogenesis in middle-adult SVZ/SGZ. Expression of autophagy-related genes and autophagic activity were significantly declined in the middle-adult subventricular/subgranular zone (SVZ/SGZ) homogenates and cultured NPCs, and inhibiting autophagy by siRNA interference resulted in impaired proliferation and differentiation of NPCs. In present study, we revealed a close connection between impaired autophagy and adult neurogenetic decline.

Whether and how autophagy affects adult neurogenesis remains poorly understood. Autophagy, a highly conserved process of cellular degradation, is essential for maintaining cellular homeostasis and normal function. Understanding the mechanism of adult neurogenesis and stimulating neurogenesis will benefit the mitigation of neurodegenerative diseases. However, this process declines with aging, which is implicated in the recession of brain function and neurodegeneration. Adult neurogenesis is the ongoing generation of functional new neurons from neural progenitor cells (NPCs) in the mammalian brain.

Fischer Pool Table Serial Numbers